CONTRAVE works in 2 parts of the brain to help reduce hunger and control cravings- 2 main issues that contribute to weight gain. Across 3 studies, patients who were overweight or obese lost approximately 2-4x more weight over 1 year by adding CONTRAVE than with diet and exercise alone. Nearly half of patients taking CONTRAVE lost 5% or more body weight and kept it off. Individual results may vary.